منابع مشابه
Structure-based function prediction: approaches and applications.
The ever increasing number of protein structures determined by structural genomic projects has spurred much interest in the development of methods for structure-based function prediction. Existing methods can be roughly classified in two groups: some use a comparative approach looking for the presence of structural motifs possibly associated with a known biochemical function. Other methods try ...
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Genome sequencing projects have ciphered millions of protein sequence, which require knowledge of their structure and function to improve the understanding of their biological role. Although experimental methods can provide detailed information for a small fraction of these proteins, computational modeling is needed for the majority of protein molecules which are experimentally uncharacterized....
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The three-dimensional structure of a protein is determined by the network of covalent and non-covalent interactions. An exact description of the governing forces requires to take into account quantum effects which makes the system too complex for most computational analyses. Depending on the application, a simpler representation can make such analyses feasible while still capturing the relevant...
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ژورنال
عنوان ژورنال: Seibutsu Butsuri
سال: 2000
ISSN: 0582-4052,1347-4219
DOI: 10.2142/biophys.40.314